PKM

Across TCGA cell cohorts, PKM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,819 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PKM-associated GO terms across cancer lineages are Protein depolymerization, Ribonucleoside diphosphate metabolic process, and Nucleoside diphosphate metabolic process. Each is linked with PKM in more than 14 cancer types. Because this analysis shows association rather than direction, both PKM-to-partner and partner-to-PKM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein depolymerization grouped by PKM-low versus PKM-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKM→partner) and Y-score (partner→PKM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Protein depolymerization →	+0.156	+1.484	<.001	<.001	3	15
SKIN	Ribonucleoside diphosphate metabolic process →	+0.111	+1.125	<.001	<.001	3	15
SKIN	Nucleoside diphosphate metabolic process →	+0.117	+1.231	<.001	<.001	3	14
BLOOD_Lymphoma	ADP catabolic process →	+0.125	+1.014	<.001	<.001	3	13
URINARY_TRACT	Regulation of Golgi inheritance →	+0.162	+1.048	.001	<.001	2	13
CNS	Purine nucleoside diphosphate catabolic process →	+0.100	+0.752	<.001	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,819 associations by consensus.

Protein depolymerization by PKM expression — BONE

Explore this box plot interactively →