PKIA

Across TCGA pan-cancer cohorts, PKIA mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PKIA data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PKIA mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PKIA expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, LSCC, and UCEC are the cancer types where PKIA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	II,III,IV	0.362	1.000	.002	18	view →
LSCC	DFS	Median	III,IV	0.445	0.913	.003	13	view →
UCEC	OS	Median	III,IV	0.254	0.787	.038	8	view →
PDAC	DFS	Median	III,IV	0.348	0.979	.004	6	view →
HNSC	DFS	Median	III,IV	1.000	0.939	.043	1	view →
LUAD	OS	Tertile	All	0.895	0.655	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PKIA–CCRCC (DFS)

Open the CCRCC breakdown →