PKD2

Across TCGA patient cohorts, PKD2 mutation is significantly associated with the total protein of many other genes, with 61 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD2-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-E2, and A-Raf_pS299. Each is linked with PKD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PKD2-to-partner and partner-to-PKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PKD2-low versus PKD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD2→partner) and Y-score (partner→PKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.599	+2.502	.001	.001	3	3
UCEC	Cyclin-E2 →	+0.134	+1.700	.012	.040	3	3
STAD	A-Raf_pS299 →	-0.115	-3.000	.038	.036	3	2
STAD	Src_pY527 →	-1.056	-3.000	<.001	.036	3	2
UCEC	Caspase-8 →	-0.258	-4.295	.001	<.001	3	2
UCEC	eEF2 →	+0.290	+2.115	.011	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

Caspase-7-cleavedD198 by PKD2 expression — UCEC

Explore this box plot interactively →