PKD2

Across TCGA cell cohorts, PKD2 mutation is significantly associated with the RNA expression of many other genes, with 34 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKD2-associated genes across cancer lineages are MTRNR2L5, RBMY1J, and NEU2. Each is linked with PKD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKD2-to-partner and partner-to-PKD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTRNR2L5 grouped by PKD2-low versus PKD2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD2→partner) and Y-score (partner→PKD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MTRNR2L5 →	+0.053	+4.807	<.001	.006	3	1
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1
LUNG_SCLC	NEU2 →	+0.020	+5.643	<.001	.002	3	1
LUNG_SCLC	IFNA2 →	+0.019	+5.029	<.001	.006	3	1
LUNG_SCLC	OR52M1 →	+0.025	+5.029	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

MTRNR2L5 by PKD2 expression — BLOOD_Myeloma

Explore this box plot interactively →