PKD1P6

Across TCGA pan-cancer cohorts, PKD1P6 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PKD1P6 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PKD1P6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PKD1P6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, KICH, and KIRC are the cancer types where PKD1P6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.730	0.548	<.001	101	view →
KICH	OS	Median	III,IV	0.347	0.942	.001	46	view →
KIRC	DFS	Quartile	All	0.521	0.765	.001	41	view →
UCS	DFS	Median	IV	0.952	0.367	.001	40	view →
THCA	OS	Quartile	II,III,IV	0.941	1.000	.002	34	view →
SKCM	DFS	Tertile	All	0.802	0.610	<.001	31	view →
LGG	DFS	Median	All	0.321	0.464	.001	27	view →
READ	OS	Median	II,III,IV	0.959	0.310	.002	25	view →
COAD	DFS	Quartile	All	0.287	0.671	.005	22	view →
BRCA	OS	Quartile	III,IV	0.973	0.841	.008	18	view →
MESO	DFS	Tertile	All	0.275	0.669	.012	18	view →
LUAD	OS	Quartile	II,III,IV	0.734	0.494	.004	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PKD1P6–HNSC (DFS)

Open the HNSC breakdown →