PKD1L3

Across TCGA patient cohorts, PKD1L3 mutation is significantly associated with the RNA expression of many other genes, with 2,782 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD1L3-associated genes across cancer lineages are NOP10, CRELD2, and ROR1. Each is linked with PKD1L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKD1L3-to-partner and partner-to-PKD1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOP10 grouped by PKD1L3-low versus PKD1L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L3→partner) and Y-score (partner→PKD1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NOP10 →	+0.349	+1.954	<.001	<.001	3	2
UCEC	CRELD2 →	+0.382	+1.483	.004	.007	3	2
UCEC	ROR1 →	+0.699	+1.736	<.001	<.001	3	2
UCEC	SLC22A4 →	-0.482	-1.347	.004	.007	3	2
UCEC	GTF2E2 →	+0.337	+2.103	.001	.003	3	2
UCEC	UBE2D3P2 →	+0.300	+2.087	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,782 associations by consensus.

NOP10 by PKD1L3 expression — UCEC

Explore this box plot interactively →