PKD1L3

Across TCGA patient cohorts, PKD1L3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD1L3-associated genes across cancer lineages are N-Cadherin, 4E-BP1, and PDCD4. Each is linked with PKD1L3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PKD1L3-to-partner and partner-to-PKD1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Cadherin grouped by PKD1L3-low versus PKD1L3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L3→partner) and Y-score (partner→PKD1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Cadherin →	+0.171	+1.415	.009	.040	3	2
UCEC	4E-BP1 →	+0.249	+2.700	.003	.005	3	2
COAD	PDCD4 →	-0.574	-3.576	.001	.002	2	2
COAD	PKC-b-II_pS660 →	-0.493	-3.169	.001	.018	3	1
COAD	TAZ →	+0.210	+3.347	.013	.004	3	1
COAD	Axl →	-0.245	-2.441	.036	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

N-Cadherin by PKD1L3 expression — UCEC

Explore this box plot interactively →