PKD1L3

Across TCGA cell cohorts, PKD1L3 RNA expression is significantly associated with the go_rna of many other GO terms, with 452 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PKD1L3-associated GO terms across cancer lineages are Positive regulation of intracellular estrogen receptor signaling pathway, RNA export from nucleus, and Regulation of cytoplasmic translation. Each is linked with PKD1L3 in more than 4 cancer types. Because this analysis shows association rather than direction, both PKD1L3-to-partner and partner-to-PKD1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular estrogen receptor signaling pathway grouped by PKD1L3-low versus PKD1L3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1L3→partner) and Y-score (partner→PKD1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.101	+0.007	.001	.003	3	5
SOFT_TISSUE	RNA export from nucleus →	+0.086	+0.005	<.001	.003	3	4
SOFT_TISSUE	Regulation of cytoplasmic translation →	+0.081	+0.010	<.001	.006	3	4
BLOOD_Lymphoma	Chemical synaptic transmission, postsynaptic →	-0.063	-0.023	<.001	.006	2	5
SOFT_TISSUE	Constitutive heterochromatin formation →	+0.069	+0.006	.003	.007	2	4
SOFT_TISSUE	Neuronal ion channel clustering →	-0.090	-0.007	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 452 associations by consensus.

Positive regulation of intracellular estrogen receptor signaling pathway by PKD1L3 expression — BREAST

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