PKD1L1

Across TCGA pan-cancer cohorts, PKD1L1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated PKD1L1 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PKD1L1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PKD1L1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LUAD, and ACC are the cancer types where PKD1L1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.762	0.621	.002	36	view →
LUAD	OS	Median	II,III,IV	0.343	0.700	<.001	21	view →
ACC	DFS	Median	All	0.195	0.748	.003	15	view →
PRAD	DFS	Median	All	0.125	0.776	<.001	12	view →
LIHC	DFS	Median	All	0.259	0.560	.013	12	view →
KIRP	OS	Median	All	0.566	0.904	<.001	9	view →
SKCM	OS	Median	IV	0.179	0.727	<.001	9	view →
SARC	DFS	Median	All	0.153	0.594	.013	6	view →
ESCA	DFS	Median	All	0.205	0.537	.021	6	view →
SCLC	DFS	Median	III,IV	0.137	0.546	.042	6	view →
READ	DFS	Median	III,IV	0.269	0.744	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

PKD1L1–UCEC (DFS)

Open the UCEC breakdown →