PKD1

Across TCGA patient cohorts, PKD1 mutation is significantly associated with the RNA expression of many other genes, with 8,485 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PKD1-associated genes across cancer lineages are ENPP2, JPT2, and ZWINT. Each is linked with PKD1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PKD1-to-partner and partner-to-PKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP2 grouped by PKD1-low versus PKD1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1→partner) and Y-score (partner→PKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ENPP2 →	-0.853	-3.700	<.001	.001	3	5
BLCA	JPT2 →	+0.408	+1.914	.007	.009	3	5
COAD	ZWINT →	+0.623	+2.405	<.001	<.001	3	5
COAD	TIPIN →	+0.619	+2.058	<.001	<.001	3	5
UCEC	UHRF1 →	+0.712	+1.595	<.001	<.001	3	5
HNSC	CST3 →	-0.785	-3.436	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,485 associations by consensus.

ENPP2 by PKD1 expression — STAD

Explore this box plot interactively →