PKD1

Across TCGA cell cohorts, PKD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,551 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PKD1-associated GO terms across cancer lineages are Calcium-independent cell-matrix adhesion, Metanephric proximal tubule development, and Pre-mRNA catabolic process. Each is linked with PKD1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PKD1-to-partner and partner-to-PKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Calcium-independent cell-matrix adhesion grouped by PKD1-low versus PKD1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1→partner) and Y-score (partner→PKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Calcium-independent cell-matrix adhesion →	+0.244	+1.645	<.001	<.001	3	20
URINARY_TRACT	Metanephric proximal tubule development →	+0.279	+1.551	<.001	<.001	3	18
BONE	Pre-mRNA catabolic process →	+0.201	+1.930	<.001	<.001	3	17
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.175	+1.704	<.001	<.001	3	17
BONE	Subtelomeric heterochromatin formation →	+0.118	+1.549	.001	<.001	3	17
BONE	Regulation of cilium assembly →	+0.056	+1.380	.003	.005	2	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,551 associations by consensus.

Calcium-independent cell-matrix adhesion by PKD1 expression — BONE

Explore this box plot interactively →