PKD1

Across TCGA cell cohorts, PKD1 mutation is significantly associated with the RNA expression of many other genes, with 2,201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PKD1-associated genes across cancer lineages are PPIAL4A, TMBIM1, and LINC02693. Each is linked with PKD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PKD1-to-partner and partner-to-PKD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4A grouped by PKD1-low versus PKD1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PKD1→partner) and Y-score (partner→PKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PPIAL4A →	+0.082	+3.807	<.001	.003	3	5
BLOOD_Leukemia	TMBIM1 →	-1.316	-2.163	<.001	.002	3	4
BLOOD_Leukemia	LINC02693 →	+0.972	+1.955	.001	<.001	3	4
URINARY_TRACT	OR8B12 →	+0.009	+3.044	<.001	.004	3	3
URINARY_TRACT	LIPN →	+0.086	+3.047	<.001	.002	3	3
BLOOD_Lymphoma	UNC119B →	+0.538	+2.189	.009	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,201 associations by consensus.

PPIAL4A by PKD1 expression — BLOOD_Myeloma

Explore this box plot interactively →