Across TCGA pan-cancer cohorts, PJA2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PJA2’s most consistent transcriptional readouts.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PJA2 RNA is repressed in tumor relative to normal tissue. In most cancer types PJA2 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.
BLCA, COAD, and THCA are the cancer types where PJA2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PJA2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.