PJA1

Across TCGA patient cohorts, PJA1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PJA1-associated genes across cancer lineages are mTOR_pS2448, PKC-delta_pS664, and Rab25. Each is linked with PJA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PJA1-to-partner and partner-to-PJA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by PJA1-low versus PJA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PJA1→partner) and Y-score (partner→PJA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.156	-2.379	<.001	<.001	3	3
UCEC	PKC-delta_pS664 →	-0.078	-1.502	.031	.025	3	2
UCEC	Rab25 →	-0.216	-1.584	.031	.017	3	2
UCEC	Shc_pY317 →	-0.179	-1.754	<.001	.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.439	+1.415	.014	.040	3	2
UCEC	Caspase-8 →	-0.206	-3.143	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

mTOR_pS2448 by PJA1 expression — UCEC

Explore this box plot interactively →