PJA1

Across TCGA cell cohorts, PJA1 mutation is significantly associated with the drug of many other genes, with 44 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PJA1-associated genes across cancer lineages are Docetaxel, Bosutinib, and Lenalidomide. Each is linked with PJA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PJA1-to-partner and partner-to-PJA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Docetaxel grouped by PJA1-low versus PJA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PJA1→partner) and Y-score (partner→PJA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Docetaxel →	+0.757	+2.710	.005	.027	3	1
LARGE_INTESTINE	Bosutinib →	+0.457	+2.807	.009	.046	3	1
LARGE_INTESTINE	Lenalidomide →	+0.300	+2.807	.028	.046	3	1
LARGE_INTESTINE	MK-1775 →	+0.292	+3.061	.048	.010	3	1
LARGE_INTESTINE	Talazoparib →	+0.721	+2.871	.007	.021	3	1
LARGE_INTESTINE	Epirubicin →	+0.566	+2.871	.032	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Docetaxel by PJA1 expression — LARGE_INTESTINE

Explore this box plot interactively →