PIWIL4

Across TCGA pan-cancer cohorts, PIWIL4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIWIL4 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIWIL4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIWIL4 expression acts as an unfavorable survival marker, although some lineages such as OV and UCEC show a favorable association.

LUAD, OV, and UCEC are the cancer types where PIWIL4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	III,IV	0.212	0.859	<.001	20	view →
OV	DFS	Median	All	1.000	0.863	.034	4	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.598	.043	4	view →
GBM	DFS	Median	All	0.853	0.635	.007	2	view →
CCRCC	OS	Median	II,III,IV	1.000	0.449	.032	2	view →
PDAC	OS	Quartile	III,IV	0.696	0.872	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIWIL4–LUAD (DFS)

Open the LUAD breakdown →