PIWIL4

Across TCGA patient cohorts, PIWIL4 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIWIL4-associated genes across cancer lineages are PCNA, eEF2, and eIF4E. Each is linked with PIWIL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIWIL4-to-partner and partner-to-PIWIL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PIWIL4-low versus PIWIL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL4→partner) and Y-score (partner→PIWIL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.246	+3.169	<.001	<.001	3	3
UCEC	eEF2 →	+0.260	+2.321	.022	.033	3	2
UCEC	eIF4E →	+0.185	+2.058	.006	<.001	3	2
UCEC	ERK2 →	+0.179	+1.777	.003	.002	3	2
UCEC	GAPDH →	+0.358	+2.584	.036	.010	3	2
UCEC	GATA6 →	-0.123	-1.800	.019	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

PCNA by PIWIL4 expression — UCEC

Explore this box plot interactively →