PIWIL4

Across TCGA cell cohorts, PIWIL4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,688 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIWIL4-associated GO terms across cancer lineages are Positive regulation of protein localization to plasma membrane, Regulation of protein localization to cell periphery, and Negative regulation of leukocyte activation. Each is linked with PIWIL4 in more than 8 cancer types. Because this analysis shows association rather than direction, both PIWIL4-to-partner and partner-to-PIWIL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to plasma membrane grouped by PIWIL4-low versus PIWIL4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL4→partner) and Y-score (partner→PIWIL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of protein localization to plasma membrane →	+0.086	+1.192	.001	<.001	3	9
STOMACH	Regulation of protein localization to cell periphery →	+0.088	+1.582	<.001	<.001	3	9
BREAST	Negative regulation of leukocyte activation →	+0.097	+0.570	.001	.009	2	9
OVARY	RNA folding →	-0.100	-0.875	<.001	.001	3	8
PANCREAS	Negative regulation of cell activation →	+0.107	+1.078	<.001	.001	3	8
PANCREAS	Protein localization to endoplasmic reticulum →	+0.126	+1.006	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,688 associations by consensus.

Positive regulation of protein localization to plasma membrane by PIWIL4 expression — STOMACH

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