PIWIL4

Across TCGA cell cohorts, PIWIL4 mutation is significantly associated with the drug of many other genes, with 38 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIWIL4-associated genes across cancer lineages are AKT inhibitor VIII, GSK2110183B, and YM201636. Each is linked with PIWIL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIWIL4-to-partner and partner-to-PIWIL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AKT inhibitor VIII grouped by PIWIL4-low versus PIWIL4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL4→partner) and Y-score (partner→PIWIL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AKT inhibitor VIII →	+0.341	+2.706	.023	.049	3	2
BLOOD_Leukemia	GSK2110183B →	+0.485	+2.655	.008	.044	3	2
BLOOD_Leukemia	YM201636 →	+0.360	+2.750	.018	.046	3	2
LARGE_INTESTINE	5-Fluorouracil →	+0.549	+2.991	.046	.018	3	1
LARGE_INTESTINE	Niraparib →	+0.347	+2.868	.040	.022	3	1
LARGE_INTESTINE	Sabutoclax →	+0.441	+2.991	.027	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

AKT inhibitor VIII by PIWIL4 expression — BLOOD_Leukemia

Explore this box plot interactively →