PIWIL1

Across TCGA pan-cancer cohorts, PIWIL1 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated PIWIL1 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PIWIL1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PIWIL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, KIRC, and DLBC are the cancer types where PIWIL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.976	0.618	.001	36	view →
KIRC	OS	Median	All	0.181	0.811	.003	15	view →
DLBC	DFS	Median	II,III,IV	0.022	0.837	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
CESC	OS	Median	IV	0.095	0.592	.004	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
BRCA	OS	Median	III,IV	0.111	0.544	.029	6	view →
SKCM	DFS	Median	All	1.000	0.619	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

PIWIL1–UCEC (DFS)

Open the UCEC breakdown →