PIWIL1

Across TCGA patient cohorts, PIWIL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,012 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible PIWIL1-associated GO terms across cancer lineages are Negative regulation of Wnt signaling pathway, Regulation of double-strand break repair via homologous recombination, and Regulation of epithelial to mesenchymal transition. Each is linked with PIWIL1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PIWIL1-to-partner and partner-to-PIWIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Wnt signaling pathway grouped by PIWIL1-low versus PIWIL1-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL1→partner) and Y-score (partner→PIWIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	Negative regulation of Wnt signaling pathway →	+0.023	+0.131	<.001	<.001	3	12
SCLC	Regulation of double-strand break repair via homologous recombination →	+0.052	+0.435	<.001	<.001	3	11
KIRC	Regulation of epithelial to mesenchymal transition →	+0.028	+0.086	<.001	<.001	3	11
LGG	Regulation of synaptic vesicle priming →	+0.061	+0.020	<.001	<.001	2	12
UCS	Mitotic cytokinesis →	+0.045	+0.664	<.001	.009	2	12
UCS	Positive regulation of protein-containing complex assembly →	+0.030	+0.763	<.001	.001	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,012 associations by consensus.

Negative regulation of Wnt signaling pathway by PIWIL1 expression — SARC

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