PIWIL1

Across TCGA cell cohorts, PIWIL1 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIWIL1-associated genes across cancer lineages are LYZL2, RBMY1F, and C16orf90. Each is linked with PIWIL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIWIL1-to-partner and partner-to-PIWIL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL2 grouped by PIWIL1-low versus PIWIL1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL1→partner) and Y-score (partner→PIWIL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LYZL2 →	+0.020	+4.643	<.001	.004	3	1
LUNG_SCLC	RBMY1F →	+0.782	+4.643	<.001	.004	3	1
LUNG_SCLC	C16orf90 →	+0.061	+4.044	<.001	.009	3	1
LUNG_SCLC	ASIC5 →	+0.073	+4.269	<.001	.005	3	1
LUNG_SCLC	RDH8 →	+0.090	+4.523	<.001	.003	3	1
LUNG_NSCLC_LUAD	KCNK10 →	+0.137	+3.943	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

LYZL2 by PIWIL1 expression — LUNG_SCLC

Explore this box plot interactively →