PITX1

Across TCGA patient cohorts, PITX1 mutation is significantly associated with the RNA expression of many other genes, with 2,949 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITX1-associated genes across cancer lineages are RN7SKP100, RN7SL149P, and MTND6P20. Each is linked with PITX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX1-to-partner and partner-to-PITX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP100 grouped by PITX1-low versus PITX1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX1→partner) and Y-score (partner→PITX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RN7SKP100 →	+0.141	+5.327	<.001	.006	3	2
LGG	RN7SL149P →	+0.137	+4.987	<.001	.009	3	2
SKCM	MTND6P20 →	+0.089	+7.816	<.001	.008	3	2
LUAD	RNA5SP457 →	+0.527	+4.990	<.001	.009	3	2
LUAD	MIR8053 →	+0.371	+5.343	.005	.006	3	2
UCEC	MIR6877 →	+0.298	+1.800	.004	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,949 associations by consensus.

RN7SKP100 by PITX1 expression — LGG

Explore this box plot interactively →