PITX1

Across TCGA cell cohorts, PITX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,108 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PITX1-associated GO terms across cancer lineages are Hindlimb morphogenesis, Embryonic hindlimb morphogenesis, and mRNA alternative polyadenylation. Each is linked with PITX1 in more than 12 cancer types. Because this analysis shows association rather than direction, both PITX1-to-partner and partner-to-PITX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hindlimb morphogenesis grouped by PITX1-low versus PITX1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX1→partner) and Y-score (partner→PITX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Hindlimb morphogenesis →	+1.150	+2.670	.001	<.001	2	13
BLOOD_Myeloma	Embryonic hindlimb morphogenesis →	+1.108	+2.670	.001	<.001	2	12
OESOPHAGUS	mRNA alternative polyadenylation →	+0.095	+1.841	.002	.003	3	8
UPPER_AERODIGESTIVE_TRACT	Myelination in peripheral nervous system →	+0.107	+1.376	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Peripheral nervous system axon ensheathment →	+0.107	+1.376	<.001	<.001	3	8
PANCREAS	Regulation of protein localization to endoplasmic reticulum →	+0.101	+1.725	.004	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,108 associations by consensus.

Hindlimb morphogenesis by PITX1 expression — BLOOD_Myeloma

Explore this box plot interactively →