PITX1

Across TCGA cell cohorts, PITX1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PITX1-associated genes across cancer lineages are ADAM2, PRR23B, and LCE1C. Each is linked with PITX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX1-to-partner and partner-to-PITX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by PITX1-low versus PITX1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX1→partner) and Y-score (partner→PITX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ADAM2 →	+0.153	+5.539	<.001	.003	3	1
BLOOD_Leukemia	PRR23B →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	LCE1C →	+0.628	+4.922	<.001	.009	3	1
LARGE_INTESTINE	UTF1 →	+0.015	+3.217	<.001	.006	3	1
LARGE_INTESTINE	C10orf53 →	+0.013	+3.217	<.001	.006	3	1
LARGE_INTESTINE	PABPC1L2B →	+0.015	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ADAM2 by PITX1 expression — BLOOD_Leukemia

Explore this box plot interactively →