PITX1

Across TCGA cell cohorts, PITX1 mutation is significantly associated with the mutation status of many other genes, with 2,609 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PITX1-associated genes across cancer lineages are HOXD3, VAV3, and MYBPC3. Each is linked with PITX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PITX1-to-partner and partner-to-PITX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXD3 grouped by PITX1-low versus PITX1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX1→partner) and Y-score (partner→PITX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HOXD3 →	+3.000	+3.662	.007	.007	1	3
LUNG_NSCLC_LUAD	VAV3 →	+3.415	+4.906	<.001	<.001	1	3
LUNG_NSCLC_LUAD	MYBPC3 →	+5.000	+4.187	.008	.008	1	3
LUNG_NSCLC_LUAD	CCDC39 →	+4.584	+4.584	<.001	<.001	1	3
LUNG_NSCLC_LUAD	KLHL1 →	+3.000	+4.604	.001	.001	1	3
LUNG_NSCLC_LUAD	KLF13 →	+5.000	+4.187	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,609 associations by consensus.

HOXD3 by PITX1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →