PITRM1

Across TCGA pan-cancer cohorts, PITRM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PITRM1 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PITRM1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PITRM1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where PITRM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	All	0.844	1.000	.001	35	view →
PDAC	OS	Median	IV	0.381	0.951	.006	20	view →
CCRCC	DFS	Tertile	All	0.582	0.889	.006	19	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
UCEC	DFS	Median	II,III,IV	0.870	0.555	.049	4	view →
HNSC	OS	Tertile	All	0.939	0.774	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PITRM1–LSCC (OS)

Open the LSCC breakdown →