PITRM1

Across TCGA patient cohorts, PITRM1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITRM1-associated genes across cancer lineages are Bak, Notch1, and Caspase-7-cleavedD198. Each is linked with PITRM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PITRM1-to-partner and partner-to-PITRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by PITRM1-low versus PITRM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITRM1→partner) and Y-score (partner→PITRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Bak →	+0.163	+2.501	.004	.010	3	3
UCEC	Notch1 →	+0.126	+1.676	.001	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.430	+1.479	.009	.006	3	3
COAD	Rad50 →	-0.338	-3.169	.001	.017	3	2
COAD	Rictor →	-1.147	-2.450	.008	.020	3	2
COAD	ATM →	-0.551	-3.169	.001	.018	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Bak by PITRM1 expression — COAD

Explore this box plot interactively →