PITRM1

Across TCGA cell cohorts, PITRM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,512 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PITRM1-associated GO terms across cancer lineages are Regulation of aggrephagy, Protein localization to endosome, and Negative regulation of cilium assembly. Each is linked with PITRM1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PITRM1-to-partner and partner-to-PITRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of aggrephagy grouped by PITRM1-low versus PITRM1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PITRM1→partner) and Y-score (partner→PITRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of aggrephagy →	+0.181	+0.850	<.001	<.001	3	8
LUNG_NSCLC_LUAD	Protein localization to endosome →	+0.113	+0.699	<.001	.003	3	8
LIVER	Negative regulation of cilium assembly →	+0.076	+0.843	.005	.008	3	8
LARGE_INTESTINE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.099	+0.632	<.001	<.001	3	8
LIVER	Phosphatidylinositol biosynthetic process →	+0.067	+1.075	.002	.007	2	9
LIVER	Actin polymerization or depolymerization →	+0.154	+0.963	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,512 associations by consensus.

Regulation of aggrephagy by PITRM1 expression — BONE

Explore this box plot interactively →