PITRM1

Across TCGA cell cohorts, PITRM1 mutation is significantly associated with the RNA expression of many other genes, with 447 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PITRM1-associated genes across cancer lineages are AWAT2, OR10K1, and TTC19. Each is linked with PITRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITRM1-to-partner and partner-to-PITRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AWAT2 grouped by PITRM1-low versus PITRM1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITRM1→partner) and Y-score (partner→PITRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AWAT2 →	+0.016	+4.643	<.001	.008	3	2
BLOOD_Leukemia	OR10K1 →	+0.413	+2.971	<.001	.003	3	2
LARGE_INTESTINE	TTC19 →	+0.565	+2.158	.002	.004	3	2
LARGE_INTESTINE	RPF1 →	+0.657	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	ZNF639 →	+0.472	+3.169	.007	.009	3	2
LARGE_INTESTINE	RWDD3 →	+0.436	+2.584	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 447 associations by consensus.

AWAT2 by PITRM1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →