PITPNM2

Across TCGA patient cohorts, PITPNM2 mutation is significantly associated with the RNA expression of many other genes, with 5,409 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITPNM2-associated genes across cancer lineages are LDHA, AP2B1, and TIMM21. Each is linked with PITPNM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both PITPNM2-to-partner and partner-to-PITPNM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LDHA grouped by PITPNM2-low versus PITPNM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNM2→partner) and Y-score (partner→PITPNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LDHA →	+0.627	+2.078	<.001	<.001	3	4
UCEC	AP2B1 →	+0.350	+1.844	.001	<.001	3	4
UCEC	TIMM21 →	+0.476	+2.088	<.001	<.001	3	4
UCEC	ZNHIT3 →	+0.441	+1.908	<.001	<.001	3	3
UCEC	TAF9 →	+0.568	+1.710	<.001	<.001	3	3
READ	MIR1229 →	+0.354	+4.653	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,409 associations by consensus.

LDHA by PITPNM2 expression — UCEC

Explore this box plot interactively →