PITPNM2

Across TCGA patient cohorts, PITPNM2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITPNM2-associated genes across cancer lineages are eEF2, ACC1, and p38-MAPK_pT180_Y182. Each is linked with PITPNM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PITPNM2-to-partner and partner-to-PITPNM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by PITPNM2-low versus PITPNM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNM2→partner) and Y-score (partner→PITPNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.267	+2.222	.009	.009	3	3
UCEC	ACC1 →	+0.291	+1.169	.005	.017	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.342	-1.152	.008	.048	3	3
UCEC	Caspase-7-cleavedD198 →	+0.852	+1.736	<.001	<.001	3	3
SKCM	GSK-3a-b_pS21_S9 →	-0.420	-1.807	.014	.026	3	3
UCEC	eIF4E →	+0.207	+3.183	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eEF2 by PITPNM2 expression — UCEC

Explore this box plot interactively →