PITPNM2-AS1

Across TCGA pan-cancer cohorts, PITPNM2-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PITPNM2-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where PITPNM2-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PITPNM2-AS1 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, THCA, and COAD are the cancer types where PITPNM2-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PITPNM2-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	−0.157	<.001	5	view →
THCA	All	All	−0.029	<.001	5	view →
COAD	All	All	+0.064	.013	4	view →
KICH	All	All	−0.050	.001	4	view →
LIHC	All	II,III,IV	−0.150	.008	3	view →
KIRP	All	All	−0.063	.005	2	view →
BRCA	All	III,IV	−0.046	.004	2	view →
HNSC	All	II,III,IV	+0.021	.045	2	view →
LUAD	Female	II,III,IV	−0.140	.026	1	view →
READ	All	All	+0.072	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PITPNM2-AS1–LUSC

Open the LUSC breakdown →