PITPNM1

Across TCGA patient cohorts, PITPNM1 mutation is significantly associated with the total protein of many other genes, with 71 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PITPNM1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Smad4. Each is linked with PITPNM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PITPNM1-to-partner and partner-to-PITPNM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by PITPNM1-low versus PITPNM1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNM1→partner) and Y-score (partner→PITPNM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.534	+3.338	<.001	.004	3	4
UCEC	4E-BP1 →	+0.251	+2.029	.004	.005	3	3
COAD	Smad4 →	+0.173	+1.882	.001	.031	3	3
COAD	YAP_pS127 →	-0.309	-3.000	.010	.034	3	3
UCEC	eEF2 →	+0.316	+1.716	.006	.003	3	2
UCEC	eIF4E →	+0.205	+2.662	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

Caspase-7-cleavedD198 by PITPNM1 expression — COAD

Explore this box plot interactively →