PITPNA

Across TCGA patient cohorts, PITPNA RNA expression is significantly associated with the go_rna of many other GO terms, with 7,162 significant associations in total. THCA shows the largest number of these associations.

The most reproducible PITPNA-associated GO terms across cancer lineages are Positive regulation of isotype switching to IgA isotypes, Regulation of small GTPase mediated signal transduction, and Piecemeal microautophagy of the nucleus. Each is linked with PITPNA in more than 30 cancer types. Because this analysis shows association rather than direction, both PITPNA-to-partner and partner-to-PITPNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of isotype switching to IgA isotypes grouped by PITPNA-low versus PITPNA-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNA→partner) and Y-score (partner→PITPNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Positive regulation of isotype switching to IgA isotypes →	+0.154	+0.901	<.001	<.001	3	31
SCLC	Regulation of small GTPase mediated signal transduction →	+0.042	+0.827	<.001	<.001	3	31
SCLC	Piecemeal microautophagy of the nucleus →	+0.077	+0.731	<.001	<.001	3	31
UCS	Obsolete ncRNA export from nucleus →	+0.065	+0.679	.001	.001	3	30
SCLC	7-methylguanosine RNA capping →	+0.106	+0.664	.005	.004	2	31
SCLC	Telomere capping →	+0.111	+0.743	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,162 associations by consensus.

Positive regulation of isotype switching to IgA isotypes by PITPNA expression — SCLC

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