PITPNA

Across TCGA patient cohorts, PITPNA mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITPNA-associated genes across cancer lineages are ATM, JNK_pT183_Y185, and JNK2. Each is linked with PITPNA in more than 1 cancer types. Because this analysis shows association rather than direction, both PITPNA-to-partner and partner-to-PITPNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PITPNA-low versus PITPNA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNA→partner) and Y-score (partner→PITPNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.480	-2.986	.018	.035	3	2
UCEC	JNK_pT183_Y185 →	-0.207	-1.986	.006	.032	3	1
UCEC	JNK2 →	+0.270	+3.331	.002	.005	3	1
UCEC	MSH2 →	-0.314	-2.973	.002	.035	3	1
UCEC	p62 Lck ligand →	+0.446	+3.331	.002	.005	3	1
UCEC	Annexin-1 →	+0.778	+2.341	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ATM by PITPNA expression — UCEC

Explore this box plot interactively →