PITPNA

Across TCGA cell cohorts, PITPNA mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PITPNA-associated genes across cancer lineages are RBMY1J, OR5V1, and ADAM7. Each is linked with PITPNA in more than 1 cancer types. Because this analysis shows association rather than direction, both PITPNA-to-partner and partner-to-PITPNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1J grouped by PITPNA-low versus PITPNA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITPNA→partner) and Y-score (partner→PITPNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RBMY1J →	+0.006	+4.977	<.001	.007	3	1
SKIN	OR5V1 →	+0.016	+4.977	<.001	.007	3	1
LARGE_INTESTINE	ADAM7 →	+0.007	+4.930	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.591	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.042	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

RBMY1J by PITPNA expression — SKIN

Explore this box plot interactively →