PITHD1

Across TCGA patient cohorts, PITHD1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,536 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PITHD1-associated genes across cancer lineages are PPP1R12B, MPDZ, and PLCL1. Each is linked with PITHD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both PITHD1-to-partner and partner-to-PITHD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PITHD1 versus PPP1R12B in OV, with a Pearson correlation of 0.53.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITHD1→partner) and Y-score (partner→PITHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PPP1R12B →	+1.311	+0.497	<.001	<.001	3	5
OV	MPDZ →	+1.221	+0.436	<.001	<.001	3	4
GBM	PLCL1 →	+1.108	+0.341	<.001	<.001	3	4
BRCA	CNTN4 →	+0.759	+0.292	<.001	.007	3	4
BRCA	CACNA2D1 →	+1.130	+0.457	<.001	<.001	3	4
GBM	NEGR1 →	+1.205	+0.421	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,536 associations by consensus.

PITHD1 vs PPP1R12B — OV

Explore this scatter interactively →