PITHD1

Across TCGA patient cohorts, PITHD1 mutation is significantly associated with the RNA expression of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITHD1-associated genes across cancer lineages are TAF13P2, LINC02546, and MON1B. Each is linked with PITHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITHD1-to-partner and partner-to-PITHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAF13P2 grouped by PITHD1-low versus PITHD1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITHD1→partner) and Y-score (partner→PITHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TAF13P2 →	+0.312	+5.513	<.001	.004	3	2
SKCM	LINC02546 →	+0.166	+5.037	.007	.009	3	2
UCEC	MON1B →	+0.616	+3.223	.001	.009	3	1
UCEC	LILRB5 →	+0.536	+3.298	.001	.008	3	1
UCEC	MLX →	+0.748	+3.213	<.001	.009	3	1
UCEC	MS4A4A →	+0.810	+3.210	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

TAF13P2 by PITHD1 expression — SKCM

Explore this box plot interactively →