PITHD1

Across TCGA patient cohorts, PITHD1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITHD1-associated genes across cancer lineages are Tuberin, VHL, and c-Met_pY1235. Each is linked with PITHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITHD1-to-partner and partner-to-PITHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by PITHD1-low versus PITHD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITHD1→partner) and Y-score (partner→PITHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.330	+3.000	.034	.037	3	1
UCEC	VHL →	-1.064	-3.000	.006	.036	3	1
UCEC	c-Met_pY1235 →	+0.105	+2.817	.014	.036	3	1
UCEC	INPP4B →	-0.468	-3.000	.012	.036	2	1
UCEC	p62 Lck ligand →	+0.687	+2.817	<.001	.036	2	1
UCEC	Cyclin-B1 →	+0.798	+3.000	.013	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Tuberin by PITHD1 expression — UCEC

Explore this box plot interactively →