PITHD1

Across TCGA cell cohorts, PITHD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,056 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PITHD1-associated GO terms across cancer lineages are Negative regulation of mRNA splicing, via spliceosome, DNA replication-dependent chromatin assembly, and Mitotic chromosome condensation. Each is linked with PITHD1 in more than 13 cancer types. Because this analysis shows association rather than direction, both PITHD1-to-partner and partner-to-PITHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA splicing, via spliceosome grouped by PITHD1-low versus PITHD1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PITHD1→partner) and Y-score (partner→PITHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of mRNA splicing, via spliceosome →	+0.116	+0.886	<.001	<.001	3	14
BONE	DNA replication-dependent chromatin assembly →	+0.167	+0.875	<.001	<.001	3	13
BONE	Mitotic chromosome condensation →	+0.229	+0.867	<.001	<.001	3	13
BONE	Mitotic spindle elongation →	+0.205	+0.804	.001	<.001	3	12
BLOOD_Lymphoma	Negative regulation of RNA splicing →	+0.072	+0.547	<.001	.008	3	12
BONE	Mitotic spindle midzone assembly →	+0.205	+0.804	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,056 associations by consensus.

Negative regulation of mRNA splicing, via spliceosome by PITHD1 expression — BONE

Explore this box plot interactively →