PISD

Across TCGA patient cohorts, PISD mutation is significantly associated with the RNA expression of many other genes, with 954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PISD-associated genes across cancer lineages are ABHD17AP9, RNA5SP54, and RNA5SP198. Each is linked with PISD in more than 2 cancer types. Because this analysis shows association rather than direction, both PISD-to-partner and partner-to-PISD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD17AP9 grouped by PISD-low versus PISD-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PISD→partner) and Y-score (partner→PISD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ABHD17AP9 →	+0.051	+3.745	<.001	.005	3	3
LUAD	RNA5SP54 →	+0.623	+7.930	<.001	.008	3	2
CESC	RNA5SP198 →	+0.218	+4.559	<.001	.006	3	2
BLCA	MTCO2P32 →	+0.125	+5.147	<.001	.003	3	2
BLCA	SLC25A5P9 →	+0.043	+5.618	<.001	.002	3	2
UCEC	MIR3928 →	+0.447	+2.664	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 954 associations by consensus.

ABHD17AP9 by PISD expression — STAD

Explore this box plot interactively →