PISD

Across TCGA patient cohorts, PISD mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PISD-associated genes across cancer lineages are FOXO3a_pS318_S321, PKC-delta_pS664, and Caspase-7-cleavedD198. Each is linked with PISD in more than 1 cancer types. Because this analysis shows association rather than direction, both PISD-to-partner and partner-to-PISD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by PISD-low versus PISD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PISD→partner) and Y-score (partner→PISD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.130	-3.312	.025	.010	3	2
UCEC	PKC-delta_pS664 →	-0.141	-3.169	.011	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.870	+3.341	.001	.005	3	2
UCEC	eEF2 →	+0.492	+2.999	.003	.035	3	1
UCEC	A-Raf_pS299 →	-0.199	-3.000	<.001	.036	3	1
UCEC	FoxM1 →	+0.268	+2.999	.026	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FOXO3a_pS318_S321 by PISD expression — UCEC

Explore this box plot interactively →