PISD

Across TCGA cell cohorts, PISD RNA expression is significantly associated with the go_rna of many other GO terms, with 3,812 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PISD-associated GO terms across cancer lineages are P-body assembly, Negative regulation of chromosome condensation, and Regulation of protein localization to endoplasmic reticulum. Each is linked with PISD in more than 9 cancer types. Because this analysis shows association rather than direction, both PISD-to-partner and partner-to-PISD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-body assembly grouped by PISD-low versus PISD-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PISD→partner) and Y-score (partner→PISD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	P-body assembly →	+0.104	+0.825	.002	.002	3	10
BONE	Negative regulation of chromosome condensation →	+0.139	+0.970	.001	.001	3	10
SOFT_TISSUE	Regulation of protein localization to endoplasmic reticulum →	+0.088	+0.862	<.001	<.001	3	10
URINARY_TRACT	Mitochondrial protein catabolic process →	+0.229	+1.109	.002	.001	3	10
BLOOD_Lymphoma	Retrograde transport, endosome to Golgi →	+0.066	+0.945	<.001	<.001	3	10
BLOOD_Lymphoma	Viral translational termination-reinitiation →	+0.100	+1.067	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,812 associations by consensus.

P-body assembly by PISD expression — URINARY_TRACT

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