PISD

Across TCGA cell cohorts, PISD mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PISD-associated genes across cancer lineages are LY6G6F, SPEM3, and NAT2. Each is linked with PISD in more than 1 cancer types. Because this analysis shows association rather than direction, both PISD-to-partner and partner-to-PISD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LY6G6F grouped by PISD-low versus PISD-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PISD→partner) and Y-score (partner→PISD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	LY6G6F →	+0.020	+5.169	<.001	.004	3	1
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	1
BLOOD_Leukemia	NAT2 →	+0.045	+3.551	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

LY6G6F by PISD expression — BONE

Explore this box plot interactively →