PIRT

Across TCGA pan-cancer cohorts, PIRT Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PIRT data layer compared with 21 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIRT Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PIRT expression acts as an unfavorable survival marker.

LUAD, ESCA, and UCEC are the cancer types where PIRT Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.141	0.812	<.001	24	view →
ESCA	DFS	Median	II,III,IV	0.155	0.525	.007	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PIRT–LUAD (OS)

Open the LUAD breakdown →