PIRT

Across TCGA patient cohorts, PIRT mutation is significantly associated with the RNA expression of many other genes, with 2,890 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIRT-associated genes across cancer lineages are LINC01975, RN7SL381P, and MIR3928. Each is linked with PIRT in more than 1 cancer types. Because this analysis shows association rather than direction, both PIRT-to-partner and partner-to-PIRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01975 grouped by PIRT-low versus PIRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIRT→partner) and Y-score (partner→PIRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01975 →	+0.189	+1.775	.003	.007	3	1
UCEC	RN7SL381P →	+0.477	+3.708	.004	<.001	3	1
UCEC	MIR3928 →	+0.339	+2.216	<.001	.007	3	1
UCEC	DYNLL2 →	+0.455	+2.716	.003	.003	3	1
UCEC	MIR5094 →	+0.356	+1.890	.005	.005	3	1
UCEC	PGDP1 →	+0.503	+3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,890 associations by consensus.

LINC01975 by PIRT expression — UCEC

Explore this box plot interactively →