PIRT

Across TCGA patient cohorts, PIRT mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIRT-associated genes across cancer lineages are ATM, eEF2, and eIF4E. Each is linked with PIRT in more than 1 cancer types. Because this analysis shows association rather than direction, both PIRT-to-partner and partner-to-PIRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by PIRT-low versus PIRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIRT→partner) and Y-score (partner→PIRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.515	-2.321	.005	.006	3	2
UCEC	eEF2 →	+0.371	+2.999	.012	.035	3	1
UCEC	eIF4E →	+0.214	+3.459	.014	.005	3	1
UCEC	A-Raf_pS299 →	-0.120	-2.321	.015	.034	3	1
UCEC	JNK2 →	+0.236	+2.321	.003	.006	3	1
UCEC	MEK1 →	+0.483	+3.000	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

ATM by PIRT expression — UCEC

Explore this box plot interactively →