PIPOX

Across TCGA patient cohorts, PIPOX mutation is significantly associated with the RNA expression of many other genes, with 1,480 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIPOX-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and LINC01868. Each is linked with PIPOX in more than 1 cancer types. Because this analysis shows association rather than direction, both PIPOX-to-partner and partner-to-PIPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by PIPOX-low versus PIPOX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIPOX→partner) and Y-score (partner→PIPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.465	+1.933	<.001	.002	3	2
UCEC	RNA5SP411 →	+0.847	+1.545	<.001	.007	3	2
SKCM	LINC01868 →	+0.074	+2.668	<.001	.009	3	2
LUSC	XKRY2 →	+0.019	+7.924	<.001	.008	3	2
STAD	POLR2LP1 →	+0.421	+3.620	.003	.008	3	2
UCEC	RNU6-33P →	+0.352	+1.747	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,480 associations by consensus.

RNA5SP414 by PIPOX expression — UCEC

Explore this box plot interactively →