PIPOX

Across TCGA cell cohorts, PIPOX mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIPOX-associated genes across cancer lineages are OR4F4, FCGR2B, and MYO3A. Each is linked with PIPOX in more than 1 cancer types. Because this analysis shows association rather than direction, both PIPOX-to-partner and partner-to-PIPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F4 grouped by PIPOX-low versus PIPOX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIPOX→partner) and Y-score (partner→PIPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F4 →	+0.012	+3.688	.007	.002	3	1
LARGE_INTESTINE	FCGR2B →	+0.139	+3.453	.001	.009	3	1
LARGE_INTESTINE	MYO3A →	+0.714	+3.491	<.001	.008	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

OR4F4 by PIPOX expression — LARGE_INTESTINE

Explore this box plot interactively →